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CREB inhibitor

CAS No. 1433286-70-4

CREB inhibitor( CREB inhibitor )

Catalog No. M20071 CAS No. 1433286-70-4

666-15 is a potent and selective CREB inhibitor (IC50: 81 nM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    CREB inhibitor
  • Note
    Research use only, not for human use.
  • Brief Description
    666-15 is a potent and selective CREB inhibitor (IC50: 81 nM).
  • Description
    666-15 is a potent and selective CREB inhibitor (IC50: 81 nM).
  • In Vitro
    Cell Proliferation Assay Cell Line:CTRL or MSN-overexpressing MDA-MB-231 cells Concentration:73 nM Incubation Time:For 12hours Result:Significantly blocked the cell proliferation caused by MSN overexpression.Western Blot Analysis Cell Line:NRCMs Concentration:1 μM Incubation Time:2 hour (pretreated)Result:Effectively inhibited PE-induced CREB phosphorylation.
  • In Vivo
    Animal Model:1-month-old female nude mice with MDA-MB-231 or T47D cells Dosage:10 mg/kg Administration:IP; once a week; for 11 weeks Result:Played a good role in inhibiting the growth of breast cancer.
  • Synonyms
    CREB inhibitor
  • Pathway
    Chromatin/Epigenetic
  • Target
    Epigenetic Reader Domain
  • Recptor
    CREB
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1433286-70-4
  • Formula Weight
    620.52
  • Molecular Formula
    C33H31Cl2N3O5
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 60 mg/mL (96.7 mM)
  • SMILES
    Cl.NCCCOc1cc2ccccc2cc1C(=O)NCCOc1cc2ccccc2cc1C(=O)Nc1ccc(Cl)cc1O
  • Chemical Name
    3-(3-Aminopropoxy)-N-[2-[[3-[[(4-chloro-2-hydroxyphenyl)amino]carbonyl]-2-naphthalenyl]oxy]ethyl]-2-naphthalenecarboxamide hydrochloride

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Xie F et al. Identification of a Potent Inhibitor of CREB-Mediated Gene Transcription with Efficacious in Vivo Anticancer Activity. J Med Chem. 2015 Jun 25;58(12):5075-87.
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